HANDS ON WORKSHOP IN FERMENTATION AND BIOPROCESS TECHNOLOGY, WITH EMPHASIS ON DRUG DISCOVERY AND INSTRUMENTATION.

In association with niTza Biologicals (P) Ltd., SGI Departments of Biotechnology are building on their sound reputation for high quality programmes in biotechnology by offering a four-day (1st - 4th February) workshop on state-of-the-art techniques in Fermentation Biotechnology, Drug Discovery and basic techniques in Molecular Biology and Immunology.

AIM

This workshop aims at giving the participants, undergraduate, postgraduate students, and technical staff from academia and industrial firms, invaluable “hands-on-experience” of “state-of-the-art” fermentation biotechnology techniques.

Module I: Fermentation Biotechnology (Day 1 & 2)
Presenters:
Mr.Murly KrishnaFermentation Specialist at E.I.DuPont India Pvt Ltd
Mr. Shailesh Kumar, Saint-Gobain, Performance Plastics-Biopharm
Mr. Sanil KV, Sr.Scientist, Program manager for process development and fermentation, Avesthagen
Dr. P N Panda, formally from NII, Presently Asst Prof. of SCM in Sharda University
Learning Objectives:
A Two-Day session of “hands-on-experience” of bacterial and fungal fermentation processes as implemented on industrial scales; details on applications.
Participants will also be acquainted with:
Preparation of inoculum and inculcation of fermentors
Sampling and harvesting of biomass and desired end-product
Learning outcomes:
Upon completion of this 2-day session (Module I), the participants will be able to:
1. Assemble, conduct and appraise bacterial and fungal fermentation processes.2. Measure and follow the increase in biomass spectrophotometerically by following the increase in optical density (OD) at a given wave length that is specific to growth conditions3. Construct a growth curve and determine various growth parameters, e.g., growth rate and specific growth rate.4. Detect and determine the pattern of product formation for primary and secondary metabolites.
Case Studies: A number of case studies have been added to the curriculum of this workshop so that participants may gain deeper understanding of fermentation biotechnology. This is implemented as a response to the feedback we received from last year participants and you are encouraged to appraise our workshop in the hope that we can make better our effort for next year.



Module II: Drug Discovery (Day 3)
Presenters:
Dr. Surendra Chikara,Head Genomics, Research and Development, Xcelris labs Ltd, Ahmadabad.

Prof. Surat Kumar, Head, Applied Sciences, Dayalbagh Educational Institute, Dayalbagh, Agra
Dr Amla Chopra, Head, Department of Biotechnology, Anand Engineering College, Keetham, Agra
Learning Objectives:
New Drug Target Discovery using Next Generation Genomics technology
Basic Concepts of Drug DNA interactions.
DNA Cancer Vaccine: An immunological approach for treatment of breast cancer.
Learning outcomes:
Upon completion of this 2-day session (Module I), the participants will be able to Understand:
Next generation of genomics technology.
The mechanism and mode of action of Drugs.
Validation and identification of drug target within a given pathway.
Multi-drug target recognition and development.
Concepts how the structure of drugs interact with major and minor groove of DNA.
Principle of DNA vaccine.
Difficulty working with tumor antigen.
Method for enhancing therapeutic efficacy of DNA cancer vaccine.



Module III: Bio Instrumentation (Day 4)***
Presenters:
Mr. Asit Dutta, Perkin Elmer
Dr. Arun Chopra, HCST

Principles of basic techniques used in Biotechnology
Agarose Gel Electrophoresis of DNA sample and visualise the genetic fingerprint under UV.
Sodium Dodecyle Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE) of a number of proteins. Stain, detect and visualize the protein bands after electrophoresis.
Amplification of DNA by PCR
Importance of Animal Tissue Culture
Use of Gas Chromatography
Learning Objectives:
Bioinformatics approach for identification of new drug targets
Basic Concepts of Drug DNA interactions
DNA Cancer Vaccine: An immunological approach for treatment of breast cancer
Learning outcomes:
Upon the completion of this one-day Session (Module III), participants should be able to:
Understand the principals and use of instrumentation.
*** Depending upon the time maximum techniques would be covered.


For more details login to http://www.hcst.edu.in/departments/biotechnology/workshop/index.html

“Sense plus nonsense equals bioinformatics”

~ Bertrand Russell on bioinformatics

Hell, no one can find the similarities and difference among us without a bioinformatics algorithm

Bioinformatics is the marriage between computers and lovely living organisms like you and me. The dowry in the marrage is 100000000000 US$. Bioinformaticians often marry among themselves and reproduce bioinformaticians. The information about their sequence of marriage is recorded, analysed and models of reproduction were initially made. But, later on some interestingly investigating bioinformaticians found that some bioinformatics couples gave birth of tigers instead of bioinformaticians. So, all bioinformaticians were in worry. So, they were in need to propose another model to deal with phylogeny and evolution.

Bioinformatics History

Father and mother of Bioinformatics

Bioinformatics was invented by the uncle of all biophysics. Some people believe that bioinformatics is nothing but the renamed version of biophysics. Some other believe that the bioinformatics is nothing but the biotechnology. Bioinformatics has no father and mother. It is an orphan. There is no one to claim a right. Everyone can either be a father or mother of bioinformatics. After all, it is a creation of God.

The Bioinformatician

A typical bioinformatician is one who forgets his/her name in the internet and searches for it in the internet. Typically bioinformatician will talk about match, mismatch, score, score values, PDB, PDF, EBI, NCBI, PERL, CGI, and Gnome and Ptome.

The basis of Bioinformatic Analysis

Similar sequence of letters has to pronounced similarly. The words pronounced similarly will have similar meaning and those are the products of same nerds. The algorithms to find the difference and similarities among foools and intellects is too lengthy and when implemented in mainframes it would occupy terabytes of data.

The Applications of Bioinformatics

Yeah, I have designed yet another drug, Try it now

Bioinformatics helps you to find your match at all levels. Ask a bioinformatician. They would tell you who would be your right match, who would be your wrong match, lost match. In simple terms, bioinformaticians are match makers. They do watch and play cricket match, football match and so soo zoo zoo match.

The Achievements

So far 10 trillion personalized drugs have been designed, synthesized and marketed, consumed with the help of bioinformatics technology. No one survived after the consumption of the drug. There is a big tie and lie between industry and bioinformatics.